Resveratrol
A polyphenol antioxidant found in grapes and berries, studied for cardiovascular and skin wellness support.
Quick Answer: 30-Second Overview
- Resveratrol is a natural polyphenol compound found in red grapes, berries and peanuts.
- It is known for its antioxidant properties and potential role in supporting cardiovascular health.
- Trans-resveratrol is the biologically active form most commonly used in supplements.
- Research has explored its relationship with sirtuin activation and healthy aging.
- Common supplemental doses range from 100mg to 500mg per serving.
What Is Resveratrol?
Resveratrol is a stilbenoid, a type of natural phenol produced by certain plants in response to stress, injury or fungal infection.
It is most abundantly found in the skin of red grapes, which is why red wine has been a primary source of research interest.
Resveratrol exists in two forms: cis-resveratrol and trans-resveratrol. The trans form is the more biologically active and stable variant.
As a polyphenol antioxidant, resveratrol helps neutralize free radicals and may support the body's defense against oxidative stress.
The compound gained widespread attention through the 'French Paradox' — the observation that French populations had relatively low cardiovascular disease rates despite a diet rich in saturated fats.
How It Works in the Body
Antioxidant Activity
Resveratrol helps neutralize free radicals and reactive oxygen species, supporting the body's antioxidant defense systems.
Sirtuin Activation
Resveratrol has been studied for its ability to activate SIRT1, a sirtuin enzyme involved in cellular health and longevity pathways.
Anti-Inflammatory Support
Research suggests resveratrol may modulate inflammatory pathways, including NF-kB and COX-2 signaling.
Cardiovascular Support
Resveratrol may support endothelial function, healthy blood vessel dilation and lipid metabolism.
Potential Health Benefits
Cardiovascular Health
Resveratrol may support heart health through antioxidant activity, endothelial function and healthy lipid metabolism.
Skin Wellness
Antioxidant properties may support skin protection against environmental oxidative stress and promote a youthful appearance.
Anti-Aging Support
Sirtuin activation and antioxidant activity make resveratrol a compound of interest in aging research.
Metabolic Wellness
Some studies suggest resveratrol may support insulin sensitivity and metabolic health markers.
Brain Health
Preliminary research explores resveratrol's potential neuroprotective properties through antioxidant and anti-inflammatory mechanisms.
Scientific Evidence Overview
Extensive laboratory studies demonstrate resveratrol's antioxidant, anti-inflammatory and sirtuin-activating properties at the cellular level.
Animal studies have shown promising results for lifespan extension and metabolic health, though results vary by species and dose.
Human clinical trials are more limited. Some studies show improvements in inflammatory markers and endothelial function, but results are mixed.
Resveratrol has low oral bioavailability due to rapid metabolism. Micronized and liposomal formulations may improve absorption.
Important: Dietary supplements cannot replace a balanced diet, adequate sleep, regular exercise or medical treatment. Individual results may vary.
Natural Food Sources
Red Grapes
The skin of red grapes is the richest dietary source of resveratrol.
Red Wine
Contains resveratrol extracted from grape skins during fermentation.
Blueberries
Contain small amounts of resveratrol along with other beneficial anthocyanins.
Cranberries
A source of resveratrol and other polyphenol antioxidants.
Peanuts
Contain trace amounts of resveratrol in the skin.
Japanese Knotweed
Polygonum cuspidatum is a major commercial source for resveratrol supplements.
Dosage & Usage
| Form | Typical Dose | Timing |
|---|---|---|
| Trans-Resveratrol Capsules | 100-500mg per serving | Taken with food, often with a fat source for absorption |
| Micronized Resveratrol | 100-250mg per serving | Enhanced absorption formulation, taken with or without food |
| Liposomal Resveratrol | 50-200mg per serving | Liposomal delivery may improve bioavailability |
Always follow label directions and consult a healthcare professional for personalized guidance.
Who May Consider Resveratrol
Cardiovascular-conscious adults
Those interested in supporting heart health through antioxidant and endothelial support.
Skin wellness enthusiasts
Individuals seeking internal antioxidant support for skin protection and radiance.
Healthy aging advocates
People interested in sirtuin activation and longevity-related supplementation.
Active adults
Those looking for antioxidant support to complement an active lifestyle.
Safety & Interactions
General Safety
Resveratrol has been studied at doses up to 1000mg daily with generally good tolerability. Mild digestive effects may occur at higher doses.
Blood Thinning
Resveratrol may have mild antiplatelet effects. Those taking anticoagulant medications should consult a healthcare professional.
Hormone-Sensitive Conditions
Resveratrol has weak estrogenic activity. Individuals with hormone-sensitive conditions should consult a doctor before use.
Drug Interactions
Resveratrol may affect the metabolism of certain medications through CYP450 enzyme interactions. Consult your healthcare provider.
How to Choose a Quality Product
- Look for trans-resveratrol specifically, as it is the more biologically active form.
- Check the label for the amount of trans-resveratrol per serving, not just total resveratrol.
- Consider micronized or liposomal formulations for improved bioavailability.
- Choose brands that provide third-party testing and COA documentation.
- Prefer products from cGMP-certified, FDA-registered manufacturing facilities.
Ingredient Comparisons
Resveratrol vs NMN
Resveratrol is an antioxidant polyphenol; NMN is an NAD+ precursor. They work through different mechanisms but are sometimes combined for complementary support.
Resveratrol vs Quercetin
Both are polyphenol antioxidants. Quercetin is a flavonoid found in onions and apples, while resveratrol is a stilbenoid from grapes. They may have complementary effects.
Trans-Resveratrol vs Regular Resveratrol
Trans-resveratrol is the more stable and biologically active form. Regular resveratrol supplements may contain a mix of cis and trans forms.
AIDEVI Products with Resveratrol
AIDEVI Resveratrol Complex
Trans-resveratrol formula with complementary polyphenols. 60 capsules, 30 servings. Designed for antioxidant and cardiovascular support.
View Product Details →Frequently Asked Questions
References & Review Information
Scientific References
- Berman AY, et al. The therapeutic potential of resveratrol. J Med Food. 2017.
- Smoliga JM, et al. Resveratrol and human health. Critical Reviews in Food Science. 2018.
- Wang S, et al. Biological effects of resveratrol. Life Sciences. 2020.
- Gambini J, et al. Effects of resveratrol on health. Free Radical Biology. 2019.
Last Reviewed: July 2026
This ingredient guide is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional before starting any new supplement.
Explore More Ingredients
Learn about other key ingredients in AIDEVI formulations.